Glucose tolerance and insulin secretion in parents and children with familial dwarfism and high plasma immunoreactive growth hormone (IR-HGH) and familial isolated growth hormone deficiency.

Several studies have revealed that the majority of dwarfs with isolated growth hormone deficiency show low insulin response to glycemic and arginine stimulation tests and some have a tendency to develop glucose intolerance (Frohmann, MacGillivray and Aceto 1967, Merimee, Rabinovitz, Rimoin and McKusick 1968, Gold, Spector, Samaan and Pearson 1968). On the basis of sensitivity to exogenous insulin and the plasma insulin response to oral glucose, Merimee, Hall, Rimoin and McKusick (1969) found that some dwarfs with isolated growth hormone de-